Fifty-two newly discovered genes that are critical for hearing have been found by testing gene-modified ‘knockout’ mice. The newly identifed genes will provide insights into the causes of hearing loss in humans. The study published Oct. 12 in Nature Communications was carried out by the International Mouse Phenotyping Consortium (IMPC), which includes the Mouse Biology Program at the University of California, Davis.
Synthetic DNA Approach is Key to Startup’s New Drug
By Lisa Howard
The way Justin Siegel describes it, ordering synthetic DNA is almost as easy as ordering a pair of shoes online.
“You just type it in — or if the protein has been sequenced at one point, we can copy and paste — order it, and it shows up five days later.”
Initiative Aims to Support Responsible CRISPR Gene Editing
By Trina Wood
The federal Defense Advanced Research Projects Agency (DARPA) last week announced the Safe Genes program to explore innovative genetic techniques to support bio-innovation and combat biological threats. The effort, supported by a $65 million grant from DARPA over four years, aims to harness gene editing tools in a safe, responsible manner to maximize the benefits of these technologies while minimizing their inherent risks.
By Ana Lucia Cordova-Kreylos
The UC Davis Office of Research this week (July 10) announced the launch of the Microbiome Special Research Program (SRP), designed to leverage and build upon the broad and deep expertise in microbiome science across the university.
“UC Davis has incredible breadth and depth in microbiome research with over 100 laboratories actively pursuing projects with links to agriculture, environment, energy and human and animal health,” said Cameron Carter, interim vice chancellor for research at UC Davis. “The decision to invest in a platform to empower these teams was obvious given our strength in these areas and our potential to charter new frontiers that address some of our world’s most pressing issues.”
By Diane Nelson
The bioinformatics company Illumina has donated a state-of the-art DNA sequencer to a global plant-breeding effort to fight malnutrition and poverty in Africa by improving the continent’s traditional crops. UC Davis is partnering in the African Orphan Crop Consortium, which is working to map and make public the genomes of 101 indigenous African foods.
These “orphan” crops are crucial to African livelihood and nutrition, but have been mostly ignored by science and seed companies because they are not traded internationally like commodities such as rice, corn, and wheat.
By Dawn Rowe
The UC Davis Mouse Biology Program (MBP) has received an award of $414,000 from the National Institutes of Health to move towards sustainable, environment-friendly technology for its high-containment vivarium for mutant mice. The grant will also improve animal health and welfare, ergonomics for vivarium staff, and operational efficiencies.
Going ‘green” is a multi-step process that will take place over the next 12 months, and led by Kristin Grimsrud, associate director of vivaria and veterinary care for the program.
By Diane Nelson
Our genes can influence how we respond to stress. Science shows that some people are more genetically predisposed than others to develop depression and anxiety in response to stressful situations.
What’s more, researchers say that chronic exposure to stressful conditions—such as poverty, family discord, and poor nutrition—can alter the way genes behave in children and adolescents, making them more susceptible to depression, anxiety, and other negative effects of stress.
By Carlos Villatoro
Imagine a world where maladies such as cystic fibrosis, Huntington’s Disease, or sickle cell anemia no longer exist. While the U.S. is far from achieving this lofty goal, it recently came a step closer at the California National Primate Research Center (CNPRC), where scientists have efficiently used CRISPR/Cas9 technology to modify the genes of rhesus macaque embryos.
The research, recently published in the latest edition of Human Molecular Genetics, paves the way for future studies where the possibility of birthing gene-edited monkeys that can serve as models for new therapies is greatly increased.
Represents Most Successful Group of Flowering Plants
By Pat Bailey
Today (April 12), UC Davis researchers announced in Nature Communications that they have unlocked a treasure-trove of genetic information about lettuce and related plants, releasing the first comprehensive genome assembly for lettuce and the huge Compositae plant family.
Garden lettuce, or Lactuca sativa, is the plant species that includes a salad bar’s worth of lettuce types, ranging from iceberg to romaine. With an annual on-farm value of more than $2.4 billion, it is the most valuable fresh vegetable and one of the 10 most valuable crops, overall, in the United States.
By Lisa Howard
Gut bacteria have been getting a lot of attention lately (yogurt, anyone?) but it turns out the soil in your own back yard is teeming with microbial life. According to Kate Scow, a professor of soil science and microbial ecology at UC Davis, a quarter teaspoon of soil can easily contain a billion bacterial cells. And she estimates there can be 10,000 to 50,000 different taxa of microbes in a single teaspoon. Soil is one of the most complex and diverse ecosystems on the planet, and it is one that is essential for human life through all the functions it provides: the breakdown of organic materials, food production, water purification, greenhouse gas reduction, and pollution cleanup, just to name a few.