Regeneration of a lost limb is arguably one of the seven wonders of biology. While you can’t grow a new arm, a humble tadpole can grow a new tail in a week. Seeking a better understanding of limb regeneration, Min Zhao, professor of dermatology and ophthalmology at the University of California, Davis, and graduate student Fernando Ferreira (also at University of Minho, Portugal) are studying the relationship of redox players, like oxygen and hydrogen peroxide, with bioelectricity, including membrane potential and electric currents, to pinpoint how a tadpole can regrow an amputated tail.
By Aditi Risbud Bartl
Finding a fast and inexpensive way to detect specific strains of bacteria and viruses is critical to food safety, water quality, environmental protection and human health. However, current methods for detecting illness-causing strains of bacteria such as E. coli require either time-intensive biological cell cultures or DNA amplification approaches that rely on expensive laboratory equipment.
Louis Pasteur famously compared science and its application to a tree and it’s fruit. The path from a fundamental discovery to application can be a long and winding one, but rewarding none the less.
Professor Ken Burtis, faculty advisor to the Chancellor and Provost, recently came across an exciting example. Burtis was looking for a study for his first year seminar class when he found a paper from Andrea Crisanti’s lab at Imperial College London. Crisanti’s team was able to wipe out a lab population of Anopheles gambiae mosquitoes by introducing a disrupted gene for sex determination and using CRISPR “gene drive” technology to spread it through the population. Within eight generations, there were no female mosquitoes left for breeding.
By Sofie Bates
Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal life. So there is a substantial amount of quality control during the process of forming an egg cell, or ovum, that weeds out all but the highest quality cells. New research from Neil Hunter’s laboratory at UC Davis reveals the surprising way that this critical oocyte quality control process works.
By Trina Wood
UC Davis researchers announce in the Proceedings of the National Academy of Sciences this week a breakthrough in understanding which cells afford optimal protection against Salmonella infection—a critical step in developing a more effective and safe vaccine against a bacterium that annually kills an estimated one million people worldwide.
By Aditi Risbud Bartl
As an undergraduate physics major, Maureen Kinyua discovered her passion for science—combined with a sincere interest in helping others—could lead to a fruitful career in engineering.
“I liked how you could combine physics, chemistry and biology into something more applied,” she said. “Engineering also gave me a way to mix my interest in science while actually doing good for the environment.”
By Aditi Risbud Bartl
In the last decade, researchers in academia and the technology sector have been racing to unlock the potential of artificial intelligence. In parallel with federally-funded efforts from the National Institutes of Health and the National Science Foundation, heavy-hitters such as Microsoft, Facebook and Google are deeply invested in artificial intelligence.
As part of the BRAIN Initiative, many UC Davis investigators are studying the nervous system and developing new technologies to investigate brain function.
By Anahita Hamidi
Telomeres are repetitive nucleotide sequences that act as protective “caps” at the end of DNA strands. As cells age, either as a function of time or as a result of stress and poor health, telomeres tend to shorten. As such, telomere length can be used as a crude biological marker of health and well-being.
A recent study by researchers at the University of California Davis, Center for Mind and Brain, measured changes in telomere length, telomerase (the enzyme which replenishes telomeres), and telomere-regulating genes in a group of individuals who participated in a month-long Insight meditation retreat.
I recently returned from the 2018 International One Health Congress(#IOHC) in beautiful Saskatoon, Canada. Insight, inspiration and networking were in abundance at the biennial conference, which drew more than 800 participants from 60 countries to hear renowned experts and researchers in One Health. It was a privilege to share the work of the UC Davis One Health Institute (OHI) and PREDICT.
Back in my office, many IOHC sessions and conversations remain top of mind. Here are my key takeaways:
26 Percent Of Nonhuman Primates Lost Pregnancies Despite Not Showing Symptoms
By AJ Cheline
Research from several institutions, including the California National Primate Research Center at UC Davis, suggests that more women could be losing their pregnancies to the Zika virus without knowing they are infected.
The study, published in Nature Medicine July 2, found 26 percent of nonhuman primates infected with Zika during early stages of pregnancy experienced miscarriage or stillbirth even though the animals showed few signs of infection.