By Dawn Rowe
The UC Davis Mouse Biology Program (MBP) has received an award of $414,000 from the National Institutes of Health to move towards sustainable, environment-friendly technology for its high-containment vivarium for mutant mice. The grant will also improve animal health and welfare, ergonomics for vivarium staff, and operational efficiencies.
Prof. Kent Lloyd, director of the UC Davis Mouse Biology Program, in the lab. Gene-edited and “knockout” mice have become a vital tool in biomedical research. (Karin Higgins/UC Davis photo)
Going ‘green” is a multi-step process that will take place over the next 12 months, and led by Kristin Grimsrud, associate director of vivaria and veterinary care for the program.
Virus-suppressing Bacteria Could Control Transmission by Mosquitoes
Mosquitos infected with the bacteria Wolbachia are significantly worse vectors for dengue virus, but how to establish and spread Wolbachia in an urban mosquito population is unclear. A study published May 30 in the open access journal PLOS Biology shows that over time, strategic releases of mosquitoes infected with the dengue-suppressing bacteria may be enough to allow the virus-resistant insects to spread across large cities.
Leading the work are Professor Michael Turelli, UC Davis Department of Evolution and Ecology, and colleagues from Scott O’Neill’s “Eliminate Dengue Program” based at Monash University, Melbourne.
Scientists hope to control the spread of malaria using genetically modified mosquitoes that are resistant to the parasite.
By Trina Wood
UC Davis vector biologist Greg Lanzaro is taking part in the newly-announced UC Irvine Malaria Initiative to genetically engineer new strains of mosquitoes to fight malaria in Africa. The project, led by UCI’s pioneering vector biologist Anthony James, will bring together experts in molecular biology, entomology, public health and community engagement from across the UC system.
By Carlos Villatoro
Imagine a world where maladies such as cystic fibrosis, Huntington’s Disease, or sickle cell anemia no longer exist. While the U.S. is far from achieving this lofty goal, it recently came a step closer at the California National Primate Research Center (CNPRC), where scientists have efficiently used CRISPR/Cas9 technology to modify the genes of rhesus macaque embryos.
The research, recently published in the latest edition of Human Molecular Genetics, paves the way for future studies where the possibility of birthing gene-edited monkeys that can serve as models for new therapies is greatly increased.
By Kathy Keatley Garvey
Researchers in Professor Bruce Hammock’s laboratory at UC Davis are studying mechanisms involved in blocking angiogenesis — the formation of new blood vessels. The findings may lead to new methods for preventing cancer growth and targeting other diseases, the researchers report.
Postdoc Amy Rand is studying how certain fats can affect growth of blood vessels in tumors.
A recently-published study from Hammock’s lab describes a novel lipid-signaling molecule that can change fundamental biological processes involved in human health and disease. It builds on landmark research by the Judah Folkman laboratory of Harvard Medical School, which earlier showed that cutting off blood vessels that feed a cancerous tumor could stop its growth.
Possible new route to regenerating function lost in diabetes
In people with type I diabetes, insulin-producing beta cells in the pancreas die and are not replaced. Without these cells, the body loses the ability to control blood glucose. Researchers at the University of California, Davis have now discovered a possible new route to regenerating beta cells, giving insight into the basic mechanisms behind healthy metabolism and diabetes. Eventually, such research could lead to better treatment or cures for diabetes.
Nutritionist Looks at Fortifying Staple Foods To Boost Health
By Lisa Howard
Reina Engle-Stone was halfway through her biology degree at Cornell University when she discovered global nutrition.
Her introduction was a nutritional epidemiology class, and almost immediately she was hooked. “You could take biology and apply it to other things. I thought, this is great, this is what I want to do,” she says.
Reina Engle-Stone, assistant professor of nutrition at UC Davis, helps develop programs to fortify staple foods with nutrients.
By Holly Ober
Two UC Davis graduates have started a company incubated in the TEAM manufacturing facility at the UC Davis Department of Biomedical Engineering.
Arshia Firouzi and Gurkern Sufi met in 2011 as Freshmen living in Tercero Dormitories at UC Davis and quickly became friends. Arshia majored in Electrical Engineering and Gurkern in Biotechnology, and they worked with the mentorship of Professor Marc Facciotti to explore their shared interest in the intersection of electronics and biology. In 2015 they won a VentureWell grant for a research project, which they pursued in TEAM’s Molecular Prototyping and Bioinnovation Laboratory. By the end of their project, they had come up with an idea that grew into a company that could usher in a new era for laboratories all over the world.
By Carlos Villatoro
The successful application of an alternative male contraceptive in rhesus macaque monkeys at the California National Primate Research Center is paving the way for human clinical trials.
For over a century, men who did not want to father a child had only one permament option for contraception. But according to the results of a study conducted at the California National Primate Research Center (CNPRC), there could be an alternative to a vasectomy that is as efficient and has the potential to be easily and successfully reversible.
By Pat Bailey
A UC Davis-led study of nursing mothers in The Gambia shows how environment changes breast milk content
In a newly published study, UC Davis researchers and their colleagues, paint the picture of an elegant web of cause-and-effect that connects climate, the breast milk of nursing moms, gut microbes and the health of breast fed infants.
The research is part of a long-running. cross-disciplinary project at UC Davis studying milk and its role in nutrition. For example, last year UC Davis scientists and colleagues at Washington University St. Louis worked with both children and animal models to show how milk compounds could alter gut microbe composition and affect health. UC Davis researchers also led a consortium to study the “milk genome,” the collection of all genes related to producing milk.