The Molecular Prototyping and BioInnovation Laboratory, or “Biomaker Lab” at UC Davis is a place where students can try out their ideas and develop their own projects in biotechnology. It reflects as “maker culture” that is well-established in engineering, and growing in biological sciences.
By Holly Ober
To win the battle against heart disease, cardiologists need better ways to identify the composition of plaque most likely to rupture and cause a heart attack. Angiography allows them to examine blood vessels for constricted regions by injecting them with a contrast agent before X-raying them. But because plaque does not always result in constricted vessels, angiography can miss dangerous buildups of plaque. Intravascular ultrasound can penetrate the buildup to identify depth, but lacks the ability to identify some of the finer details about risk of plaque rupture.
Synthetic DNA Approach is Key to Startup’s New Drug
By Lisa Howard
The way Justin Siegel describes it, ordering synthetic DNA is almost as easy as ordering a pair of shoes online.
“You just type it in — or if the protein has been sequenced at one point, we can copy and paste — order it, and it shows up five days later.”
Researchers at UC Davis, the Boyce Thompson Institute (BTI) at Cornell University, the University of Minnesota and Iowa State University have received a four-year, $10.3 million “Insect Allies” award from the Defense Advance Research Projects Agency (DARPA) to engineer viruses carried by insects that can help in combatting disease, drought, and other yield-reducing stresses in maize.
Homologous Recombination Can Cause More Breaks As It Fixes Them
The traditional view of cancer is that a cell has to sustain a series of hits to its DNA before its defenses break down enough for it to turn cancerous. But cancer researchers have also found that cells can experience very rapid and widespread DNA damage that could quickly lead to cancer or developmental defects.
Now researchers at the University of California, Davis, have found that these complex chromosomal rearrangements can be triggered in a single event when a process used to repair DNA breaks, homologous recombination, goes wrong. The work is published Aug. 10 in the journal Cell.
Initiative Aims to Support Responsible CRISPR Gene Editing
By Trina Wood
The federal Defense Advanced Research Projects Agency (DARPA) last week announced the Safe Genes program to explore innovative genetic techniques to support bio-innovation and combat biological threats. The effort, supported by a $65 million grant from DARPA over four years, aims to harness gene editing tools in a safe, responsible manner to maximize the benefits of these technologies while minimizing their inherent risks.
By Ana Lucia Cordova-Kreylos
The UC Davis Office of Research this week (July 10) announced the launch of the Microbiome Special Research Program (SRP), designed to leverage and build upon the broad and deep expertise in microbiome science across the university.
“UC Davis has incredible breadth and depth in microbiome research with over 100 laboratories actively pursuing projects with links to agriculture, environment, energy and human and animal health,” said Cameron Carter, interim vice chancellor for research at UC Davis. “The decision to invest in a platform to empower these teams was obvious given our strength in these areas and our potential to charter new frontiers that address some of our world’s most pressing issues.”
By Kathy Keatley Garvey
A study of microbes that live in the nectar of flowers has turned up an unexpected result that challenges a common assumption in ecology.
It’s been widely assumed that the more easily organisms can disperse between habitats, the more similar the mix of species in those habitats will be.
By Dawn Rowe
The UC Davis Mouse Biology Program (MBP) has received an award of $414,000 from the National Institutes of Health to move towards sustainable, environment-friendly technology for its high-containment vivarium for mutant mice. The grant will also improve animal health and welfare, ergonomics for vivarium staff, and operational efficiencies.
Going ‘green” is a multi-step process that will take place over the next 12 months, and led by Kristin Grimsrud, associate director of vivaria and veterinary care for the program.
In this episode of our Three Minute Egghead podcast, UC Davis plant biologist Siobhan Brady talks about her work on roots.
Roots are the key innovation that allowed plants to conquer the land. They allow a plant to explore its environment, seeking out water and nutrients. A cell type within roots called xylem transports water and also provides support for land plants, allowing them to grow swiftly like a field of corn or reach towering heights of a sequoia.
Brady’s lab is looking at the network of genes that work together to control how xylem cells develop and grow, looking especially at the lab plant Arabidopsis, domestic tomato and its wild relatives, and the African staple crop sorghum.