Hear This: Knockout Mice Show Genes Linked to Deafness

Fifty-two newly discovered genes that are critical for hearing have been found by testing gene-modified ‘knockout’ mice. The newly identifed genes will provide insights into the causes of hearing loss in humans. The study published Oct. 12 in Nature Communications was carried out by the International Mouse Phenotyping Consortium (IMPC), which includes the Mouse Biology Program at the University of California, Davis.

Prof. Kent Lloyd, director of the UC Davis Mouse Biology Program, in the lab. Gene-edited and “knockout” mice have become a vital tool in biomedical research. (Karin Higgins/UC Davis photo)

Fabric from Fermented Tea in the Biomaker Lab

The Molecular Prototyping and BioInnovation Laboratory, or “Biomaker Lab” at UC Davis is a place where students can try out their ideas and develop their own projects in biotechnology. It reflects as “maker culture”  that is well-established in engineering, and growing in biological sciences.

“Kombucha couture” clothes made by artist Sacha Laurin (center) for Paris Fashion Week and National Geographic magazine. With Laurin are, from left, models Ghazal Gill, Grace Sanders and Ericah Howard, and reporter Bethany Crouch of CBS13 and Good Day Sacramento.

“Smart” Immune Cells: Emerging Cancer Therapy Research at UC Davis Boosted with NIH Award

By David Slipher

Assistant Professor Sean Collins, Department of Microbiology and Molecular Genetics in the UC Davis College of Biological Sciences, has received a $1.5 million award from the National Institutes of Health to advance the development of “smart” immune cells for therapies to treat cancer and other diseases. The five-year NIH Director’s New Innovator Award aims to provide new insight into how to engineer immune cells to control their recruitment and response to tumors.

Sean Collins

Assistant professor Sean Collins has received a NIH New Innovator award for work to make cancer therapies safer. Fred Greaves, UC Davis

UC Davis Mouse Biology Program Developing “Green” Mouse House

By Dawn Rowe

The UC Davis Mouse Biology Program (MBP) has received an award of $414,000 from the National Institutes of Health to move towards sustainable, environment-friendly technology for its high-containment vivarium for mutant mice.  The grant will also improve animal health and welfare, ergonomics for vivarium staff, and operational efficiencies.

Prof. Kent Lloyd, director of the UC Davis Mouse Biology Program, in the lab. Gene-edited and “knockout” mice have become a vital tool in biomedical research. (Karin Higgins/UC Davis photo)

Going ‘green” is a multi-step process that will take place over the next 12 months, and led by Kristin Grimsrud, associate director of vivaria and veterinary care for the program.

UC Davis Joins Initiative to Fight Malaria in Africa


Scientists hope to control the spread of malaria using genetically modified mosquitoes that are resistant to the parasite.

By Trina Wood

UC Davis vector biologist Greg Lanzaro is taking part in the newly-announced UC Irvine Malaria Initiative to genetically engineer new strains of mosquitoes to fight malaria in Africa. The project, led by UCI’s pioneering vector biologist Anthony James, will bring together experts in molecular biology, entomology, public health and community engagement from across the UC system.

NSF Grant Funds Math For National Security

Applying mathematics to detect chemical weapons, hidden explosives or other threats is the goal of an ongoing project at the UC Davis Department of Mathematics, supported by grants from the National Science Foundation.

Resolving blurred image with math

Blind deconvolution is a mathematical method to clarify a blurred image without knowledge of the original image, or how it was blurred. Top, original image; bottom, blurred image after blind deconvolution (Original image by Steve Byland).

Threat detection involves math at a range of levels, said Professor Thomas Strohmer, who leads the project. It can include quickly processing large amounts of data, coordinating multiple sensors, or extracting clarity from background noise.

New Type of Insulin-Producing Cell Discovered

Possible new route to regenerating function lost in diabetes

In people with type I diabetes, insulin-producing beta cells in the pancreas die and are not replaced. Without these cells, the body loses the ability to control blood glucose. Researchers at the University of California, Davis have now discovered a possible new route to regenerating beta cells, giving insight into the basic mechanisms behind healthy metabolism and diabetes. Eventually, such research could lead to better treatment or cures for diabetes.

Engineering Alums’ Startup To Make Transgenics Easier

By Holly Ober

Two UC Davis graduates have started a company incubated in the TEAM manufacturing facility at the UC Davis Department of Biomedical Engineering.

Arshia Firouzi and Gurkern Sufi met in 2011 as Freshmen living in Tercero Dormitories at UC Davis and quickly became friends. Arshia majored in Electrical Engineering and Gurkern in Biotechnology, and they worked with the mentorship of Professor Marc Facciotti to explore their shared interest in the intersection of electronics and biology. In 2015 they won a VentureWell grant for a research project, which they pursued in TEAM’s Molecular Prototyping and Bioinnovation Laboratory. By the end of their project, they had come up with an idea that grew into a company that could usher in a new era for laboratories all over the world.

New Steps in the Meiosis Chromosome Dance

Where would we be without meiosis and recombination? For a start, none of us sexually reproducing organisms would be here, because that’s how sperm and eggs are made. And when meiosis doesn’t work properly, it can lead to infertility, miscarriage, birth defects and developmental disorders.

Neil Hunter’s laboratory at the UC Davis College of Biological Sciences is teasing out the complex details of how meiosis works. In a new paper published online Jan. 6 in the journal Science, Hunter’s group describes new key players in meiosis, proteins called SUMO and ubiquitin and molecular machines called proteasomes. Ubiquitin is already well-known as a small protein that “tags” other proteins to be destroyed by proteasomes (wood chippers for proteins). SUMO is a close relative of ubiquitin.

World’s First Total-Body PET Scanner Takes A Big Step Forward

The UC Davis-based EXPLORER consortium, which aims to build a revolutionary total-body PET (positron emission tomography) scanner, has announced the selection of two industry partners to help build the prototype device. They are United Imaging Healthcare America, a North American subsidiary of Shanghai United Imaging Healthcare, and SensL Technologies of Cork, Ireland.

Positron emission tomography, or PET, scanning uses short-lived radioactive tracers to show how organs and tissues are functioning in the body, while magnetic resonance imaging (MRI) and computed tomography (CT) scans mostly show anatomy. PET scans are widely used to diagnose and track a variety of illnesses, including cancer, heart disease and Alzheimer’s disease.