A study that cast doubt on the usefulness of CRISPR-Cas9 “gene editing” technology to introduce genetic changes in animals has been retracted by the journal Nature Methods. Among those refuting the work were Professor Kent Lloyd, director of the UC Davis Mouse Biology Program, and colleagues from the International Mouse Phenotyping Consortium, whose letter was one of five published by the journal March 30.
CRISPR-Cas9 can be used to introduce very specific edits into DNA. In laboratory mice, the technology could be used to make edits in embryos that are then grown to adult mice. One of the attractions of CRISPR-Cas9 is that it is supposed to make these edits without affecting other genes.