See-through Zebrafish May Hold Clues to Ovarian Cancer

by Greg Watry

For thousands of years, animals have helped humans advance biomedical research. Early Greeks, such as Aristotle and Galen, studied animals to gain insights into anatomy, physiology and pathology. Today, model organisms, like mice, help researchers understand human diseases, opening the door to potential defenses and new therapies.

Postdoc Dena Leerberg, and Bruce Draper, associate professor of molecular and cellular biology in the UC Davis College of Biological Sciences, study reproductive development in zebrafish. David Slipher/UC Davis

UC Davis Joins DARPA-funded “Safe Genes” Program

Initiative Aims to Support Responsible CRISPR Gene Editing

By Trina Wood

The federal Defense Advanced Research Projects Agency (DARPA) last week announced the Safe Genes program to explore innovative genetic techniques to support bio-innovation and combat biological threats. The effort, supported by a $65 million grant from DARPA over four years, aims to harness gene editing tools in a safe, responsible manner to maximize the benefits of these technologies while minimizing their inherent risks.

Aedes aegypti carries yellow fever, Zika and other viruses. (CDC photo)

UC Davis Joins Initiative to Fight Malaria in Africa

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Scientists hope to control the spread of malaria using genetically modified mosquitoes that are resistant to the parasite.

By Trina Wood

UC Davis vector biologist Greg Lanzaro is taking part in the newly-announced UC Irvine Malaria Initiative to genetically engineer new strains of mosquitoes to fight malaria in Africa. The project, led by UCI’s pioneering vector biologist Anthony James, will bring together experts in molecular biology, entomology, public health and community engagement from across the UC system.

Successful CRISPR Gene Editing in Non-Human Primates

By Carlos Villatoro

Imagine a world where maladies such as cystic fibrosis, Huntington’s Disease, or sickle cell anemia no longer exist. While the U.S. is far from achieving this lofty goal, it recently came a step closer at the California National Primate Research Center (CNPRC), where scientists have efficiently used CRISPR/Cas9 technology to modify the genes of rhesus macaque embryos.

The research, recently published in the latest edition of Human Molecular Genetics, paves the way for future studies where the possibility of birthing gene-edited monkeys that can serve as models for new therapies is greatly increased.