Louis Pasteur famously compared science and its application to a tree and it’s fruit. The path from a fundamental discovery to application can be a long and winding one, but rewarding none the less.
Discoveries in basic genetics have now enabled scientists to wipe out lab populations of the malaria mosquito, Anopheles gambiae. (Anthony Cornel)
Professor Ken Burtis, faculty advisor to the Chancellor and Provost, recently came across an exciting example. Burtis was looking for a study for his first year seminar class when he found a paper from Andrea Crisanti’s lab at Imperial College London. Crisanti’s team was able to wipe out a lab population of Anopheles gambiae mosquitoes by introducing a disrupted gene for sex determination and using CRISPR “gene drive” technology to spread it through the population. Within eight generations, there were no female mosquitoes left for breeding.
A study that cast doubt on the usefulness of CRISPR-Cas9 “gene editing” technology to introduce genetic changes in animals has been retracted by the journal Nature Methods. Among those refuting the work were Professor Kent Lloyd, director of the UC Davis Mouse Biology Program, and colleagues from the International Mouse Phenotyping Consortium, whose letter was one of five published by the journal March 30.
CRISPR-Cas9 can be used to introduce very specific edits into DNA. In laboratory mice, the technology could be used to make edits in embryos that are then grown to adult mice. One of the attractions of CRISPR-Cas9 is that it is supposed to make these edits without affecting other genes.
Can you brew a hoppy beer without hops? Beer purists might regard the idea with suspicion, but researchers at UC Berkeley, with some help from UC Davis’ “Pope of Foam,” have shown that you can brew a tasty hoppy beer using gene-edited yeast to replace hop flavors.
According to Charles Denby, a former postdoctoral researcher at UC Berkeley, growing hops uses a lot of water – 50 pints of water to grow enough hops (the crumbly flowers of the hop vine) for a pint of craft beer.
Initiative Aims to Support Responsible CRISPR Gene Editing
By Trina Wood
The federal Defense Advanced Research Projects Agency (DARPA) last week announced the Safe Genes program to explore innovative genetic techniques to support bio-innovation and combat biological threats. The effort, supported by a $65 million grant from DARPA over four years, aims to harness gene editing tools in a safe, responsible manner to maximize the benefits of these technologies while minimizing their inherent risks.
Aedes aegypti carries yellow fever, Zika and other viruses. (CDC photo)
Scientists hope to control the spread of malaria using genetically modified mosquitoes that are resistant to the parasite.
By Trina Wood
UC Davis vector biologist Greg Lanzaro is taking part in the newly-announced UC Irvine Malaria Initiative to genetically engineer new strains of mosquitoes to fight malaria in Africa. The project, led by UCI’s pioneering vector biologist Anthony James, will bring together experts in molecular biology, entomology, public health and community engagement from across the UC system.
By Carlos Villatoro
Imagine a world where maladies such as cystic fibrosis, Huntington’s Disease, or sickle cell anemia no longer exist. While the U.S. is far from achieving this lofty goal, it recently came a step closer at the California National Primate Research Center (CNPRC), where scientists have efficiently used CRISPR/Cas9 technology to modify the genes of rhesus macaque embryos.
The research, recently published in the latest edition of Human Molecular Genetics, paves the way for future studies where the possibility of birthing gene-edited monkeys that can serve as models for new therapies is greatly increased.