Homologous Recombination Can Cause More Breaks As It Fixes Them
The traditional view of cancer is that a cell has to sustain a series of hits to its DNA before its defenses break down enough for it to turn cancerous. But cancer researchers have also found that cells can experience very rapid and widespread DNA damage that could quickly lead to cancer or developmental defects.
Now researchers at the University of California, Davis, have found that these complex chromosomal rearrangements can be triggered in a single event when a process used to repair DNA breaks, homologous recombination, goes wrong. The work is published Aug. 10 in the journal Cell.
By Jenna Gallegos
Scientists at the University of California, Davis have discovered that DNA sequences thought to be essential for gene activity can be expendable. Sequences once called junk sometimes call the shots instead.
Jenna Gallegos with an Arabidopsis thaliana plant. Sometimes called “thale cress,” Arabidopsis is a popular plant for laboratory studies.
Professor Alan Rose has been working for over two decades to unravel a mechanism called “intron-mediated enhancement.” I’m a graduate student in Rose’s lab, and we made an exceptional discovery in an unexceptional plant called Arabidopsis thaliana, or thale cress.
Represents Most Successful Group of Flowering Plants
By Pat Bailey
Today (April 12), UC Davis researchers announced in Nature Communications that they have unlocked a treasure-trove of genetic information about lettuce and related plants, releasing the first comprehensive genome assembly for lettuce and the huge Compositae plant family.
Lettuce belongs to a large Compositae family of plants. A lettuce flower shows the similarity to plants such as ragweed and sunflowers. (Gregory Urquiaga)
Garden lettuce, or Lactuca sativa, is the plant species that includes a salad bar’s worth of lettuce types, ranging from iceberg to romaine. With an annual on-farm value of more than $2.4 billion, it is the most valuable fresh vegetable and one of the 10 most valuable crops, overall, in the United States.
Where would we be without meiosis and recombination? For a start, none of us sexually reproducing organisms would be here, because that’s how sperm and eggs are made. And when meiosis doesn’t work properly, it can lead to infertility, miscarriage, birth defects and developmental disorders.
Neil Hunter’s laboratory at the UC Davis College of Biological Sciences is teasing out the complex details of how meiosis works. In a new paper published online Jan. 6 in the journal Science, Hunter’s group describes new key players in meiosis, proteins called SUMO and ubiquitin and molecular machines called proteasomes. Ubiquitin is already well-known as a small protein that “tags” other proteins to be destroyed by proteasomes (wood chippers for proteins). SUMO is a close relative of ubiquitin.
Full post: New Steps in the Meiosis Chromosome Dance
(809 words, 2 images, estimated 3:14 mins reading time)