A study that cast doubt on the usefulness of CRISPR-Cas9 “gene editing” technology to introduce genetic changes in animals has been retracted by the journal Nature Methods. Among those refuting the work were Professor Kent Lloyd, director of the UC Davis Mouse Biology Program, and colleagues from the International Mouse Phenotyping Consortium, whose letter was one of five published by the journal March 30.
CRISPR-Cas9 can be used to introduce very specific edits into DNA. In laboratory mice, the technology could be used to make edits in embryos that are then grown to adult mice. One of the attractions of CRISPR-Cas9 is that it is supposed to make these edits without affecting other genes.
By Ann Filmer
Some trees are better at surviving drought, fire, pests, and diseases than others. By identifying the genes responsible for these adaptations, scientists can compile a scalable database that will aid resource managers as they plan long-term conservation strategies, particularly as the climate changes.
UC Davis, Johns Hopkins University and Save the Redwoods League are working together to protect this iconic tree.
Professor David Neale, UC Davis Department of Plant Sciences, showed in preliminary research that it is feasible to sequence the redwood, which has a genome 10 times larger than ours. Redwoods are “hexaploid” with six copies of each chromosome compared to humans’ two copies.