The 2018 Nobel Prize for Physics has been awarded to Arthur Ashkin of Bell Labs, Gérard Mourou, École Polytechnique, Palaiseau, France
and the University of Michigan, Ann Arbor and Donna Strickland, University of Waterloo, Canada for work on laser pulses that led to the development of “optical tweezers” that use lasers to manipulate small objects.
The invention of optical tweezers made it possible for UC Davis biologists led by Professor Stephen Kowalczykowski and the late Professor Ron Baskin to design experiments where they could manipulate and observe single DNA molecules being copied in real time. In 2001, they used optical tweezers to move a tiny bead with a piece of DNA attached under a microscope, where they could watch a helicase enzyme unwind the DNA — the first step to copying or repairing it.
The 2016 Nobel Prize for Physics will be shared by David Thouless, F. Duncan Haldane and J. Michael Kosterlitz for their work on peculiar states of matter under extreme conditions. The three used advanced mathematics — specifically topology, the study of shapes — to build theoretical models of matter. Their work has practical implications for understanding superconductors, superfluids and thin magnetic films, and ultimately for new types of devices and technologies.
“This year’s Laureates opened the door on an unknown world where matter can assume strange states,” according to the Nobel Prize citation.
“Gnothi seauton” or “Know thyself,” said the Ancient Greeks; but they might have also said, “eat yourself.” For biologists, autophagy or “self-eating” is the process that cells use to recycle material inside the cell. It breaks down defective proteins and molecules, disposes of invading viruses and bacteria, provides an energy source when food is lacking and generally keeps cells fit and healthy. Problems in autophagy are implicated in cancer, aging, infectious disease and degenerative disorders.
Yoshinori Ohsumi after hearing he had been awarded the 2016 Nobel Prize in Physiology or Medicine.
Photo: Mari Honda
Full post: Nobel Medicine Prize for “self-eating”
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