Physics Nobel for Optical Tweezers, Enabled Single Molecule DNA Work

The 2018 Nobel Prize for Physics has been awarded to Arthur Ashkin of Bell Labs, Gérard Mourou, École Polytechnique, Palaiseau, France
and the University of Michigan, Ann Arbor and Donna Strickland, University of Waterloo, Canada for work on laser pulses that led to the development of “optical tweezers” that use lasers to manipulate small objects. 

The invention of optical tweezers made it possible for UC Davis biologists led by Professor Stephen Kowalczykowski and the late Professor Ron Baskin to design experiments where they could manipulate and observe single DNA molecules being copied in real time. In 2001, they used optical tweezers to move a tiny bead with a piece of DNA attached under a microscope, where they could watch a helicase enzyme unwind the DNA — the first step to copying or repairing it.