A new technique developed at UC Davis may have broken the barrier to rapid assembly of pure protein synthesis machinery outside of living cells.
E. coli bacteria tagged with different colors produced different mixtures of proteins. Together, the bacterial consortium makes all the proteins needed for mRNA translation/protein synthesis (Fernando Villarreal, UC Davis)
In order to reconstitute cellular reactions outside of biological systems, scientists need to produce the proteins involved. Rapid yet high purity reconstitution of the cellular reactions is critical for the high-throughput study of cellular pathways and cell-free diagnostic tests for various diseases. Reconstituting cellular reactions outside cells, however, requires the separate expression and purification of each protein required to execute the reactions. This process is expensive and time consuming, making the production of more than several proteins at once extremely challenging.
Newly published research by an international team of scientists, headed by the Jun-Yan Liu lab of Tongji University, Shanghai, China, and Bruce Hammock’s lab at UC Davis gives insight into how fish oils may be protective or harmful in animal models of acute kidney injury. This knowledge may provide promising therapeutic strategies for those suffering from acute kidney injury, formerly called acute renal failure.
Jun-Yan Liu is exploring how metabolites from oils influence kidney disease.
As the Juno space probe approached Jupiter in June last year, researchers with the Computational Infrastructure for Geodynamics’ Dynamo Working Group were starting to run simulations of the giant planet’s magnetic field on one of the world’s fastest computers. While the timing was coincidental, the supercomputer modeling should help scientists interpret the data from Juno, and vice versa.
Video: Simulation of Jupiter’s magnetic fields
“Even with Juno, we’re not going to be able to get a great physical sampling of the turbulence occurring in Jupiter’s deep interior,” Jonathan Aurnou, a geophysics professor at UCLA who leads the geodynamo working group, said in an article for Argonne National Laboratory news. “Only a supercomputer can help get us under that lid.”
For thousands of years, animals have helped humans advance biomedical research. Early Greeks, such as Aristotle and Galen, studied animals to gain insights into anatomy, physiology and pathology. Today, model organisms, like mice, help researchers understand human diseases, opening the door to potential defenses and new therapies.
Postdoc Dena Leerberg, and Bruce Draper, associate professor of molecular and cellular biology in the UC Davis College of Biological Sciences, study reproductive development in zebrafish. David Slipher/UC Davis
Signal Detection Theory is a popular and well-established idea that has influenced behavioral science for around 50 years. Essentially, the theory holds that in a predator-prey relationship, prey animals will show more wariness and be more prone to flee as predators become more common. Danger signals are ambiguous, so in what appears to be a threatening situation, animals are better off running than hanging around to see if a predator really does strike.
Now Pete Trimmer, a postdoctoral research at UC Davis, has taken a fresh look at signal detection theory and come up with what at first look like counterintuitive results. In many cases, he says, animals should actually become less cautious as the risk of predation rises.
Anxiety is a common problem for children and adults with fragile X syndrome, magnifying their struggles living with an inherited intellectual disability. New UC Davis research could lead to new ways to identify and treat their anxiety at a young age—even in infancy.
The study led by developmental psychologists Jessica Burris and Susan Rivera found that infants and young children with fragile X syndrome, unlike typically developing children, tend to have their attention specifically captured by angry faces rather than happy ones. That sort of “attentional bias” toward angry faces is a pattern associated with anxiety.
The National Science Foundation has awarded $1.6M to the University of California, Davis to analyze the complex relationships between surface water and groundwater supply, agricultural land use and the economic wellbeing of rural, disadvantaged communities.
The project is led by principal investigator Helen Dahlke, an associate professor in the UC Davis Department of Land, Air and Water Resources. The team will develop models to help guide decision-making regarding water management and land use in the state.
Helen Dahlke studies how groundwater is used and replenished in California. (Tiffany Kocis/UC Davis)
by Peter Moyle, Jeff Opperman, Amber Manfree, Eric Larson, and Joan Florshiem
The flooding in Houston is a reminder of the great damages that floods can cause when the defenses of an urban area are overwhelmed. It is hard to imagine a flood system that could have effectively contained the historic amount of rain that fell on the region—several feet in just a few days. However, these floods are a stark reminder of the increasing vulnerability of urban areas across the world and the need for comprehensive strategies to reduce risk. The evidence is clear that green infrastructure, as defined below, can increase the resiliency of flood management systems and, when managed for multiple services, can reduce flood risk for many people while also promoting a range of other benefits.
For most of us Monday’s solar eclipse was a wonderful spectacle, but some scientists were out gathering data, too. Holly Oldroyd, assistant professor in the UC Davis Department of Civil and Environmental Engineering, joined a team led by Chad Higgins at Oregon State University to measure atmospheric fluxes during the eclipse.
As night turns to day and back there are changes in atmospheric temperature and pressure, water vapor and carbon dioxide, and in emissions from soils and plants into the atmosphere. Higgins’ experiment aimed to find out whether the same kinds of changes take place during the very short “night” created by the total solar eclipse. Normally these measurements are taken over time spans of half an hour or so, so the team, which also included researchers at Lawrence Livermore National Laboratory, had to come up with ways to make accurate measurements over a couple of minutes.
Homologous Recombination Can Cause More Breaks As It Fixes Them
The traditional view of cancer is that a cell has to sustain a series of hits to its DNA before its defenses break down enough for it to turn cancerous. But cancer researchers have also found that cells can experience very rapid and widespread DNA damage that could quickly lead to cancer or developmental defects.
Now researchers at the University of California, Davis, have found that these complex chromosomal rearrangements can be triggered in a single event when a process used to repair DNA breaks, homologous recombination, goes wrong. The work is published Aug. 10 in the journal Cell.