NIH Funds Project to Model Atrial Fibrillation with Heart-on-a-Chip

By Holly Ober

Creating a model of atrial fibrillation with live human heart cells on a chip is the goal of a new $6 million, five-year grant to Professor Steven George at the UC Davis Department of Biomedical Engineering and colleagues at Washington University in St. Louis.

Steven George headshot

UC Davis biomedical engineer Steven George will grow heart cells on a chip to study atrial fibrillation.

Atrial fibrillation is an irregular heartbeat caused when the heart’s upper chambers beat chaotically and out of sync with the lower chambers, leading to a variety of health problems including stroke and death. Nearly one in ten people over the age of 65 suffer from atrial fibrillation at a cost of around $6 billion.

Engineer Takes Part in Eclipse Experiment

For most of us Monday’s solar eclipse was a wonderful spectacle, but some scientists were out gathering data, too. Holly Oldroyd, assistant professor in the UC Davis Department of Civil and Environmental Engineering, joined a team led by Chad Higgins at Oregon State University to measure atmospheric fluxes during the eclipse.

As night turns to day and back there are changes in atmospheric temperature and pressure, water vapor and carbon dioxide, and in emissions from soils and plants into the atmosphere. Higgins’ experiment aimed to find out whether the same kinds of changes take place during the very short “night” created by the total solar eclipse. Normally these measurements are taken over time spans of half an hour or so, so the team, which also included researchers at Lawrence Livermore National Laboratory, had to come up with ways to make accurate measurements over a couple of minutes.

Industry Supports UC Davis Coffee Research

The Research Center of the Specialty Coffee Association (SCA) is teaming up with the UC Davis Coffee Center to embark on a two-year project to re-evaluate the scientific assumptions, measurement tools, sensory information, and – most importantly – consumer research that forms the foundation of the coffee industry’s fundamental understanding of coffee brewing.

Students in the UC Davis “Design of Coffee” class learn engineering principles from roasting and brewing coffee.

This research is underwritten with funding from Breville, which produces high-end appliances, including coffee and tea equipment.

Pattern Discovery over Pattern Recognition: A New Way for Computers to See

Jim Crutchfield wants to teach a machine to “see” in a new way, discovering patterns that evolve over time instead of recognizing patterns based on a stored template.

It sounds like an easy task – after all, any animal with basic vision can see a moving object, decide whether it is food or a threat and react accordingly, but what comes easily to a scallop is a challenge for the world’s biggest supercomputers.

Supercomputer

CORI at Lawrence Berkeley Lab is one of the world’s fastest computers. It is named after Gerty Theresa Cori, the first woman to win a Nobel Prize for Physiology or Medicine. (NERSC/LBL photo)

NSF Grant Funds Math For National Security

Applying mathematics to detect chemical weapons, hidden explosives or other threats is the goal of an ongoing project at the UC Davis Department of Mathematics, supported by grants from the National Science Foundation.

Resolving blurred image with math

Blind deconvolution is a mathematical method to clarify a blurred image without knowledge of the original image, or how it was blurred. Top, original image; bottom, blurred image after blind deconvolution (Original image by Steve Byland).

Threat detection involves math at a range of levels, said Professor Thomas Strohmer, who leads the project. It can include quickly processing large amounts of data, coordinating multiple sensors, or extracting clarity from background noise.

New Lattice Light-Sheet Microscope To Boldly Go

New Instrument Will Enable Discovery in Biology

By Cassaundra Baber

The addition of a ground-breaking microscope to the College of Biological Sciences’ arsenal of research tools will transform the way UC Davis life scientists conduct research, researchers say. The lattice light-sheet microscope — one of approximately 25 of its type in the world — has the potential to revolutionize what is known about the living cell.

“Think about Galileo and his telescope,” said Michael Paddy, scientific coordinator for the Light Microscopy Imaging Facility in the Department of Molecular and Cellular Biology. “His invention changed astronomy and our understanding of our place in the world.”

New Types of Structures for Cage-Like Clathrates

Compounds Could Be Basis For Devices That Turn Waste Heat Into Electricity

Cage-like compounds called clathrates could be used for harvesting waste heat and turning it into electricity. UC Davis chemists just discovered a whole new class of clathrates, potentially opening new ways to make and apply these materials.

Journal cover image

UC Davis chemists discovered a new class of clathrates that break the four-bond rule. The discovery was featured on the cover of the journal Angewandte Chemie (Wiley)

Engineering Alums’ Startup To Make Transgenics Easier

By Holly Ober

Two UC Davis graduates have started a company incubated in the TEAM manufacturing facility at the UC Davis Department of Biomedical Engineering.

Arshia Firouzi and Gurkern Sufi met in 2011 as Freshmen living in Tercero Dormitories at UC Davis and quickly became friends. Arshia majored in Electrical Engineering and Gurkern in Biotechnology, and they worked with the mentorship of Professor Marc Facciotti to explore their shared interest in the intersection of electronics and biology. In 2015 they won a VentureWell grant for a research project, which they pursued in TEAM’s Molecular Prototyping and Bioinnovation Laboratory. By the end of their project, they had come up with an idea that grew into a company that could usher in a new era for laboratories all over the world.

UC Davis’ McClellan Nuclear Reactor, At 27 One of “Newest” in U.S.

By Lisa Howard

On January 20, 1990, when the nuclear reactor at McClellan Air Force Base achieved its first sustained nuclear reaction known as “criticality,” it was the newest reactor in the United States.

Six years later, when the Tennessee Valley Authority launched the Watts Bar Nuclear Generating Station, the nuclear reactor at McClellan was relegated to second newest. McClellan would go on to retain that ranking for another two decades until this past October when the Tennessee Valley Authority launched Watts Bar Unit 2.

World’s First Total-Body PET Scanner Takes A Big Step Forward

The UC Davis-based EXPLORER consortium, which aims to build a revolutionary total-body PET (positron emission tomography) scanner, has announced the selection of two industry partners to help build the prototype device. They are United Imaging Healthcare America, a North American subsidiary of Shanghai United Imaging Healthcare, and SensL Technologies of Cork, Ireland.

Positron emission tomography, or PET, scanning uses short-lived radioactive tracers to show how organs and tissues are functioning in the body, while magnetic resonance imaging (MRI) and computed tomography (CT) scans mostly show anatomy. PET scans are widely used to diagnose and track a variety of illnesses, including cancer, heart disease and Alzheimer’s disease.