From Lab Fruit Flies to Mosquito Extermination in 30 Years

Louis Pasteur famously compared science and its application to a tree and it’s fruit. The path from a fundamental discovery to application can be a long and winding one, but rewarding none the less.


Discoveries in basic genetics have now enabled scientists to wipe out lab populations of the malaria mosquito, Anopheles gambiae. (Anthony Cornel)

Professor Ken Burtis, faculty advisor to the Chancellor and Provost, recently came across an exciting example. Burtis was looking for a study for his first year seminar class when he found a paper from Andrea Crisanti’s lab at Imperial College London. Crisanti’s team was able to wipe out a lab population of Anopheles gambiae mosquitoes by introducing a disrupted gene for sex determination and using CRISPR “gene drive” technology to spread it through the population. Within eight generations, there were no female mosquitoes left for breeding.