Exploring the Role of Redox and Bioelectric Players in Tissue Regeneration

Regeneration of a lost limb is arguably one of the seven wonders of biology. While you can’t grow a new arm, a humble tadpole can grow a new tail in a week. Seeking a better understanding of limb regeneration, Min Zhao, professor of dermatology and ophthalmology at the University of California, Davis, and graduate student Fernando Ferreira (also at University of Minho, Portugal) are studying the relationship of redox players, like oxygen and hydrogen peroxide, with bioelectricity, including membrane potential and electric currents, to pinpoint how a tadpole can regrow an amputated tail.

Oxygen levels tied to sudden death from seizures

Significant drops in blood oxygen levels are more common than previously thought in patients undergoing an epileptic seizure, and may be linked to sudden, unexplained death in epilepsy, according to a report from UC Davis neurologist Masud Seyal and colleagues Lisa Bateman and Chin-Shang Li.

Seyal and his colleagues examined records of 300 seizures in 57 epilepsy patients with chronic, recurrent, unprovoked seizures. One-third of all seizures were associated with drops in blood-oxygen levels below 90 percent.

The findings suggest that some cases of SUDEP may result from the brain not signaling the patient to continue breathing during seizures, though more conclusive evidence is needed, Seyal said.