Breakthrough in Designing a Better Salmonella Vaccine

By Trina Wood

UC Davis researchers announce in the Proceedings of the National Academy of Sciences this week a breakthrough in understanding which cells afford optimal protection against Salmonella infection—a critical step in developing a more effective and safe vaccine against a bacterium that annually kills an estimated one million people worldwide.

Salmonella bacteria (red) invading human cells. Salmonella infections can cause severe disease and current vaccines are inadequate. New work in mouse models shows which cells are responsible for immunity to Salmonella and may lead to improved vaccines. Photo credit: Rocky Mountain Laboratories, NIAID, NIH